On 28th June 2012, in the Rectorate of University of Sarajevo, prof.dr. Faruk Čaklovica, Rector of the University, has promoted 11 doctors of sciences, among them MSc. Daria Ler, to doctor of biological sciences.
Dr Daria Ler has been employed at IUS since 2008 as teaching assistant at the Faculty of Engineering and Natural Sciences, Program for Genetics and Bioengineering, on following subjects: Biology, Biochemistry (I and II), Immunology, General Microbiology, and Special Topics in Bioengineering.
Dr Daria Ler made in her scientific research work notable contributions to the development of modern biological science in BiH, especially immunogenetics and proteomics, using very sophisticated and subtle scientific and technical methods. Particularly significant results were achieved in the field of basic biomedical research of human cancer and potential molecular tumor markers, using molecular-genetic and protein-biochemical methods.
To this research and scientific area belongs also her doctoral dissertation entitled "Expression and prognostic value of cAMP-dependent protein kinase A (PKA) as a molecular biomarker for tumors," defended on 27th December 2011 at the Faculty for Natural Sciences and Mathematics, University of Sarajevo, in front of the Commission members: prof. dr. Semir Bešlija, Dr. Lejla Kapur-Pojskić and prof.dr. Kasim Bajrović.
The aforementioned doctoral research, implemented molecular biological analysis, used to characterize the relative expression of cAMP-dependent protein kinase A (PKA), had an aim the development of methods for specific recognition, detection and identification of PKA protein and PKA transcript, and the validation of this interesting candidate as molecular marker for noninvasive, early detection of human breast neoplasms.
The results of optimized tests and conducted analysis, show, above all, successful determination of expression and identification of selected proteins, as well as increased expression in tumor samples analyzed on different levels of genetic information. The results also indicate that PKA is largely correlated with carcinogenesis, suggesting the benefits of this new biomarker for the screening method, and that this assays certainly represent a promising approach in the field of diagnostics, prognostics and targeted therapies for breast cancer.
