Diabetes journal published the research paper of the IUS professor

Diabetes Journal Published Research Paper of IUS Professor

The IUS professor Sabina Semiz participated in the research study carried out at the Erasmus University Medical School in Rotterdam, the Netherlands, whose results has been just published in the Diabetes.

This research study has been performed as a part of the recent participation in the ERAWEB, the European exchange program at the leading medical schools in Europe. In line with the ERAWEB focus at the factors influencing the population health and the development of possible interventions towards health improvement, Prof. Semiz has joined the team of scientists that focused their efforts to solve the complex puzzle of diabetes, which is one of the largest global health emergencies. The authors investigated 124 metabolites in the circulation which correlate with fasting glucose in the Erasmus Rucphen Family study (n=2,564) and tested the possible causal effect of each metabolite over glucose and Type 2 diabetes (T2D) by using the Mendelian randomization (MR) approach. Thus, they employed a framework based on genetic risk scores for plasma metabolite profiles followed by pathway-based sensitivity analysis, and found that small and large HDL sub-fractions might be disparate targets to treat hyperglycemia.

Diabetes is the American Diabetes Association’s premier research journal, which publishes original research about the physiology and pathophysiology of diabetes mellitus.

In addition to this paper published in the Diabetes, results of Prof. Semiz’s research at the Erasmus University Medical School in Rotterdam have been also published in the Metabolomics journal earlier this year. Importantly, here the authors developed a novel prediction model for T2D by conducting a 14-years prospective study with large sample size and wide metabolite spectrum. Thus, these results contribute to the growing efforts in metabolomics to predict Type 2 diabetes development and optimize its treatment.